The improvement of trimetazidine on exercise performance in ischemic heart disease
نویسندگان
چکیده
Ischemic heart disease (IHD) patients with a decreased exercise capacity have increased angina attack rate and poor quality of life (QOL). Conventional hemodynamic drugs show limited improvement in exercise performance. Therefore we need new drugs that may further improve exercise capacity. Trimetazidine (TMZ) exerts its anti-ischemic effect by reducing fatty acid oxidation and stimulating glucose oxidation,which induces more ATP production. Recent studies have demonstrated TMZ improve ejection fraction of the IHD patients, all these lead to a better exercise capacity and QOL.
منابع مشابه
The effect of trimetazidine added to maximal anti-ischemic therapy in patients with advanced coronary artery disease.
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